Oxidants, antioxidants and the current incurability of metastatic cancers

Watson, J. (January 2013) Oxidants, antioxidants and the current incurability of metastatic cancers. Open Biology, 3 (1). pp. 2046-2441.

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URL: http://www.ncbi.nlm.nih.gov/pubmed/23303309
DOI: 10.1098/rsob.120144

Abstract

The vast majority of all agents used to directly kill cancer cells (ionizing radiation, most chemotherapeutic agents and some targeted therapies) work through either directly or indirectly generating reactive oxygen species that block key steps in the cell cycle. As mesenchymal cancers evolve from their epithelial cell progenitors, they almost inevitably possess much-heightened amounts of antioxidants that effectively block otherwise highly effective oxidant therapies. Also key to better understanding is why and how the anti-diabetic drug metformin (the world's most prescribed pharmaceutical product) preferentially kills oxidant-deficient mesenchymal p53− −cells. A much faster timetable should be adopted towards developing more new drugs effective against p53− − cancers.

Item Type: Paper
Subjects: diseases & disorders > cancer
diseases & disorders
therapies
therapies > cancer drugs - see diseases-cancer-drugs and therapies
CSHL Authors:
Depositing User: Matt Covey
Date: 8 January 2013
Date Deposited: 14 Jan 2013 21:45
Last Modified: 14 Jan 2013 21:45
Related URLs:
URI: http://repository.cshl.edu/id/eprint/26887

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