p15(INK4B) is a potential effector of TGF-β-induced cell cycle arrest

Hannon, G. J., Beach, D. (1994) p15(INK4B) is a potential effector of TGF-β-induced cell cycle arrest. Nature, 371 (6494). pp. 257-261. ISSN 00280836 (ISSN)

URL: http://www.ncbi.nlm.nih.gov/pubmed/8078588
DOI: 10.1038/371257a0

Abstract

Transforming growth factor-beta (TGF-β) inhibits cell proliferation by inducing a G1-phase cell cycle arrest. Normal progression through G1 is promoted by the activity of the cyclin-dependent protein kinases CDK4 and CDK6, which are inhibited by the protein p16(INK4). We have isolated a new member of the p16(INK4) family, p15(INK4B). p15 expression is induced ~30-fold in human keratinocytes by treatment with TGF-β, suggesting that p15 may act as an effector of TGF-β-mediated cell cycle arrest. The gene encoding p15 is located on chromosome 9 adjacent to the p16 gene at a frequent site of chromosomal abnormality in human tumours (9p21).

Item Type: Paper
Uncontrolled Keywords: carrier protein CDK6 protein INK4B protein messenger RNA p34PSK J3 kinase p34PSK-J3 kinase protein p16 protein serine threonine kinase Protein Serine Threonine Kinases transforming growth factor beta cyclin dependent kinase amino acid sequence article biosynthesis cell cycle cell line cytology gene expression genetics human isolation and purification keratinocyte metabolism molecular cloning molecular genetics nucleotide sequence physiology chromosome 9p chromosome aberration growth inhibition human cell priority journal protein family tumor Base Sequence Carrier Proteins Cloning, Molecular Keratinocytes Molecular Sequence Data Protein-Serine-Threonine Kinases RNA, Messenger Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S.
Subjects: organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > cell regulation
organs, tissues, organelles, cell types and functions > cell types and functions
CSHL Authors:
Depositing User: Matt Covey
Date Deposited: 09 Jan 2013 17:37
Last Modified: 09 Jan 2013 17:37
Related URLs:
URI: http://repository.cshl.edu/id/eprint/26491

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