The rest is silence

Bernstein, E., Denli, A. M., Hannon, G. J. (2001) The rest is silence. RNA, 7 (11). pp. 1509-1521. ISSN 13558382 (ISSN)

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URL: http://www.ncbi.nlm.nih.gov/pubmed/11720281

Abstract

Over the past several years, RNAi and its related phenomena have emerged not only as a powerful experimental tool but also as a new mode of gene regulation. Through a combination of genetic and biochemical approaches we have learned much about the mechanisms underlying dsRNA responces. However, many of the most intriguing aspects of dsRNA-induced gene silencing have yet to be illuminated. What has become abundantly clear is that the complex and highly conserved biology underlying RNA interference is critical both for genome maintenance and for the development of complex organisms. However, it seems probable that we have only begun to reveal the diversity of biological roles played by RNAi-related process.

Item Type: Paper
Uncontrolled Keywords: double stranded RNA Caenorhabditis elegans gene amplification gene silencing genetic analysis genome Neurospora crassa nonhuman plant priority journal review RNA analysis sequence homology transcription regulation transgene Animals RNA Processing, Post-Transcriptional RNA, Double-Stranded RNA, Small Interfering RNA, Untranslated Transgenes
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing
Investigative techniques and equipment
Investigative techniques and equipment > RNAI
bioinformatics > genomics and proteomics > design > nucleic acid design > RNAI Design
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > RNAi
CSHL Authors:
Communities: CSHL labs > Hannon lab
Watson School > Publications
Depositing User: Matt Covey
Date Deposited: 09 Jan 2013 16:54
Last Modified: 09 Nov 2017 21:28
PMCID: PMC1370194
Related URLs:
URI: http://repository.cshl.edu/id/eprint/26473

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