Post-transcriptional gene silencing by double-stranded RNA

Hammond, S. M., Caudy, A. A., Hannon, G. J. (2001) Post-transcriptional gene silencing by double-stranded RNA. Nature Reviews Genetics, 2 (2). pp. 110-119. ISSN 14710056 (ISSN)

URL: http://www.ncbi.nlm.nih.gov/pubmed/11253050
DOI: 10.1038/35052556

Abstract

Imagine being able to knock out your favourite gene with only a day's work. Not just in one model system, but in virtually any organism: plants, flies, mice or cultured cells. This sort of experimental dream might one day become reality as we learn to harness the power of RNA interference, the process by which double-stranded RNA induces the silencing of homologous endogenous genes. How this phenomenon works is slowly becoming clear, and might help us to develop an effortless tool to probe gene function in cells and animals.

Item Type: Paper
Uncontrolled Keywords: Animalia Harness double stranded RNA animal biological model gene silencing metabolism review RNA processing Animals Models, Biological RNA Processing, Post-Transcriptional RNA, Double-Stranded
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > RNA regulation
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene silencing
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function
CSHL Authors:
Communities: CSHL labs > Hannon lab
Watson School > Publications
Depositing User: Matt Covey
Date: 2001
Date Deposited: 09 Jan 2013 16:55
Last Modified: 19 Sep 2014 13:52
Related URLs:
URI: http://repository.cshl.edu/id/eprint/26472

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