The Argonaute family: Tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis

Carmell, M. A., Xuan, Z., Zhang, M. Q., Hannon, G. J. (2002) The Argonaute family: Tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis. Genes and Development, 16 (21). pp. 2733-2742. ISSN 08909369 (ISSN)

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URL: http://www.ncbi.nlm.nih.gov/pubmed/12414724
DOI: 10.1101/gad.1026102

Abstract

In conclusion, Argonaute proteins comprise a highly conserved protein family that is involved in a variety of RNA silencing phenomena in a diverse set of organisms. Perhaps through RNAi-related pathways or possibly also through distinct mechanisms, Argonaute family members have a variety of biological roles. These include regulation of development and determination of stem-cell character. Through an ever-advancing understanding of the biochemistry and genetics of the Argonaute family, we may ultimately reveal the reach of these pathways into the basic biological mechanisms that underlie a variety of human diseases.

Item Type: Paper
Uncontrolled Keywords: double stranded RNA nucleotide protein protein Argonaute ribonuclease III unclassified drug biochemistry biology carcinogenesis cell fate development gene expression regulation gene mutation gene silencing genetic conservation genetics priority journal protein family protein RNA binding review RNA interference stem cell Amino Acid Sequence Animals Cell Differentiation Cell Transformation, Neoplastic Gene Expression Regulation, Developmental Humans Molecular Sequence Data RNA, Small Interfering RNA-Induced Silencing Complex Stem Cells
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > RNAi
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > argonaute proteins
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types
therapies > stem cells
CSHL Authors:
Communities: CSHL labs > Hannon lab
Depositing User: Matt Covey
Date: 2002
Date Deposited: 09 Jan 2013 16:55
Last Modified: 14 Jan 2013 22:06
Related URLs:
URI: http://repository.cshl.edu/id/eprint/26471

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