Carmell, M. A., Xuan, Z., Zhang, M. Q., Hannon, G. J.
(2002)
The Argonaute family: Tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis.
Genes and Development, 16 (21).
pp. 2733-2742.
ISSN 08909369 (ISSN)
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Abstract
In conclusion, Argonaute proteins comprise a highly conserved protein family that is involved in a variety of RNA silencing phenomena in a diverse set of organisms. Perhaps through RNAi-related pathways or possibly also through distinct mechanisms, Argonaute family members have a variety of biological roles. These include regulation of development and determination of stem-cell character. Through an ever-advancing understanding of the biochemistry and genetics of the Argonaute family, we may ultimately reveal the reach of these pathways into the basic biological mechanisms that underlie a variety of human diseases.
Item Type: |
Paper
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Uncontrolled Keywords: |
double stranded RNA
nucleotide
protein
protein Argonaute
ribonuclease III
unclassified drug
biochemistry
biology
carcinogenesis
cell fate
development
gene expression regulation
gene mutation
gene silencing
genetic conservation
genetics
priority journal
protein family
protein RNA binding
review
RNA interference
stem cell
Amino Acid Sequence
Animals
Cell Differentiation
Cell Transformation, Neoplastic
Gene Expression Regulation, Developmental
Humans
Molecular Sequence Data
RNA, Small Interfering
RNA-Induced Silencing Complex
Stem Cells |
Subjects: |
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > RNAi bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > argonaute proteins bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types therapies > stem cells |
CSHL Authors: |
|
Communities: |
CSHL labs > Hannon lab |
Depositing User: |
Matt Covey
|
Date: |
2002 |
Date Deposited: |
09 Jan 2013 16:55 |
Last Modified: |
14 Jan 2013 22:06 |
Related URLs: |
|
URI: |
http://repository.cshl.edu/id/eprint/26471 |
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