Dicer is essential for mouse development

Bernstein, E., Kim, S. Y., Carmell, M. A., Murchison, E. P., Alcorn, H., Li, M. Z., Mills, A. A., Elledge, S. J., Anderson, K. V., Hannon, G. J. (2003) Dicer is essential for mouse development. Nature Genetics, 35 (3). pp. 215-217. ISSN 10614036 (ISSN)

URL: http://www.ncbi.nlm.nih.gov/pubmed/14528307
DOI: 10.1038/ng1253

Abstract

To address the biological function of RNA interference (RNAi)-related pathways in mammals, we disrupted the gene Dicer1 in mice. Loss of Dicer1 lead to lethality early in development, with Dicer1-null embryos depleted of stem cells. Coupled with our inability to generate viable Dicer1-null embryonic stem (ES) cells, this suggests a role for Dicer, and, by implication, the RNAi machinery, in maintaining the stem cell population during early mouse development.

Item Type: Paper
Uncontrolled Keywords: RNA animal cell animal model article cell viability dicer 1 gene embryo embryo development gene gene disruption gene function gene silencing lethality mammal mouse nonhuman priority journal stem cell Amino Acid Sequence Animals DEAD-box RNA Helicases Embryonic and Fetal Development Endoribonucleases Mice Mice, Knockout Molecular Sequence Data RNA Helicases RNA Interference Stem Cells Animalia Mammalia
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > dicer
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes > dicer

bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes
organism description > animal > mammal
organism description > animal > mammal > rodent > mouse
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types
organism description > animal > mammal > rodent
CSHL Authors:
Communities: CSHL labs > Hannon lab
Watson School > Publications
Depositing User: Matt Covey
Date: 2003
Date Deposited: 09 Jan 2013 16:58
Last Modified: 19 Sep 2014 14:34
Related URLs:
URI: http://repository.cshl.edu/id/eprint/26461

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