The guardian's little helper: MicroRNAs in the p53 tumor suppressor network

He, X., He, L., Hannon, G. J. (2007) The guardian's little helper: MicroRNAs in the p53 tumor suppressor network. Cancer Research, 67 (23). pp. 11099-11101. ISSN 00085472 (ISSN)

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URL: http://www.ncbi.nlm.nih.gov/pubmed/18056431
DOI: 10.1158/0008-5472.can-07-2672

Abstract

Several microRNAs (miRNAs) have been implicated in tumor development based on both changes in their expression patterns and gene structural alterations in human tumors. However, we are only now beginning to see how miRNAs interact with classic oncogene and tumor suppressor mechanisms. Several recent studies have implicated the miR-34 family of miRNAs in the p53tumor suppressor network. The expression of miR-34a, miR-34b, and miR-34c is robustly induced by DNA damage and oncogenic stress in a p53-dependent manner. When overexpressed, miR-34 leads to apoptosis or cellular senescence, whereas reduction of miR-34 function attenuates p53-mediated cell death. These findings, together with the fact that miR-34 is down-regulated in several types of human cancer, show that miRNAs can affect tumorigenesis by working within the confines of well-known tumor suppressor pathways. ©2007 American Association for Cancer Research.

Item Type: Paper
Uncontrolled Keywords: microRNA protein p53 apoptosis cancer inhibition carcinogenesis cell death DNA damage down regulation human oncogene priority journal protein expression review senescence Animals Gene Expression Regulation, Neoplastic Humans MicroRNAs Neoplasms Tumor Suppressor Protein p53
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > miRNA
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > miRNA

bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > p53
CSHL Authors:
Communities: CSHL labs > Hannon lab
Depositing User: Matt Covey
Date: 2007
Date Deposited: 09 Jan 2013 16:52
Last Modified: 09 Jan 2013 16:52
Related URLs:
URI: http://repository.cshl.edu/id/eprint/26452

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