Nuclear speckles: a model for nuclear organelles

Lamond, A. I., Spector, D. L. (2003) Nuclear speckles: a model for nuclear organelles. Nature Reviews Molecular Cell Biology, 4. pp. 605-612. ISSN 1471-0072

URL: http://www.ncbi.nlm.nih.gov/pubmed/12923522
DOI: 10.1038/nrm1172

Abstract

Speckles are subnuclear structures that are enriched in pre-messenger RNA splicing factors and are located in the interchromatin regions of the nucleoplasm of mammalian cells. At the fluorescence-microscope level they appear as irregular, punctate structures, which vary in size and shape, and when examined by electron microscopy they are seen as clusters of interchromatin granules. Speckles are dynamic structures, and both their protein and RNA-protein components can cycle continuously between speckles and other nuclear locations, including active transcription sites. Studies on the composition, structure and behaviour of speckles have provided a model for understanding the functional compartmentalization of the nucleus and the organization of the gene-expression machinery.

Item Type: Paper
Uncontrolled Keywords: Animals Cell Cycle Cell Nucleus Cell Nucleus Structures Humans Inclusion Bodies Models, Genetic Nuclear Proteins RNA RNA-Binding Proteins Transcription, Genetic
Subjects: bioinformatics
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > nuclear speckles
CSHL Authors:
Communities: CSHL labs > Spector lab
Depositing User: Matt Covey
Date Deposited: 10 Dec 2012 20:01
Last Modified: 29 Jan 2015 16:06
Related URLs:
URI: http://repository.cshl.edu/id/eprint/26355

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