Protein phosphorylation and the nuclear organization of pre-mRNA splicing

Misteli, T., Spector, D. L. (1997) Protein phosphorylation and the nuclear organization of pre-mRNA splicing. Trends In Cell Biology, 7 (4). pp. 135-138. ISSN 0962-8924

URL: http://www.ncbi.nlm.nih.gov/pubmed/17708924
DOI: 10.1016/S0962-8924(96)20043-1

Abstract

Controlled execution of transcription and pre-mRNA splicing is crucial for proper gene expression. The organization of these essential events within the cell nucleus is only beginning to be understood. Here, we describe a model for the cellular arrangement of transcription and pre-mRNA splicing based on recent biochemical and morphological data: transcription and pre-mRNA splicing are spatially and temporally coordinated, and protein phosphorylation regulates both the activity and the subnuclear localization of pre-mRNA splicing factors in nuclear subcompartments.

Item Type: Paper
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing
bioinformatics > genomics and proteomics
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > pre-mRNA
CSHL Authors:
Communities: CSHL labs > Spector lab
Depositing User: Matt Covey
Date Deposited: 10 Dec 2012 19:56
Last Modified: 29 Jan 2015 17:44
Related URLs:
URI: http://repository.cshl.edu/id/eprint/26338

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