Dynamic organization of pre-mRNA splicing factors

Huang, S., Spector, D. L. (1996) Dynamic organization of pre-mRNA splicing factors. Journal of Cellular Biochemistry, 62 (2). pp. 191-197. ISSN 0730-2312

URL: http://www.ncbi.nlm.nih.gov/pubmed/8844399
DOI: 10.1002/(SICI)1097-4644(199608)62:2<191::AID-JCB7>3.0.CO;2-N

Abstract

Studies from several laboratories during the past few years have increased our understanding towards the dynamic organization of pre-mRNA splicing factors in the mammalian cell nucleus. Many well characterized splicing factors have been localized in a speckled pattern in the cell nucleus. Upon the activation of RNA polymerase II transcription, splicing factors are recruited to the sites of transcription from sites of reassembly and/or storage. Nascent intron-containing RNA transcripts are spliced at the sites of transcription. The speckled distribution of splicing factors in the nucleus is altered when either transcription or pre-mRNA splicing activities are interrupted suggesting that the organization of the splicing machinery in the interphase nucleus is a direct reflection of the transcriptional activity of the cell.

Item Type: Paper
Uncontrolled Keywords: Animals Cell Nucleus Humans Nuclear Proteins RNA Precursors RNA Splicing Transcription, Genetic
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing
bioinformatics > genomics and proteomics
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > pre-mRNA
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > splicing factor
CSHL Authors:
Communities: CSHL labs > Spector lab
Depositing User: Matt Covey
Date Deposited: 10 Dec 2012 19:43
Last Modified: 29 Jan 2015 19:28
Related URLs:
URI: http://repository.cshl.edu/id/eprint/26332

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