Testing tic suppression: comparing the effects of dexmethylphenidate to no medication in children and adolescents with attention-deficit/hyperactivity disorder and Tourette's disorder

Lyon, Gholson J., Samar, Stephanie M., Conelea, Christine, Trujillo, Marcel R., Lipinski, Christina M., Bauer, Christopher C., Brandt, Bryan C., Kemp, Joshua J., Lawrence, Zoe E., Howard, Jonathan, Castellanos, F. Xavier, Woods, Douglas, Coffey, Barbara J. (2010) Testing tic suppression: comparing the effects of dexmethylphenidate to no medication in children and adolescents with attention-deficit/hyperactivity disorder and Tourette's disorder. Journal of Child and Adolescent Psychopharmacology, 20 (4). pp. 283-289. ISSN 1557-8992

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URL: http://www.ncbi.nlm.nih.gov/pubmed/20807066
DOI: 10.1089/cap.2010.0032

Abstract

The aim of this study was to conduct a pilot study testing whether single-dose, immediate-release dexmethylphenidate (dMPH) can facilitate tic suppression in children and adolescents with attention-deficit/hyperactivity disorder (ADHD) and Tourette's disorder (TD) or chronic tic disorders. The primary hypothesis is that dMPH will improve behaviorally reinforced tic suppression in a standard tic suppression paradigm (TSP).Ten children with ADHD and TD were given dMPH on one visit and no medication on another, using a random crossover design. On both days, following a baseline period, subjects were reinforced for suppressing tics using a standard TSP.Thirteen subjects were enrolled; 10 subjects (mean age 12.7 +/- 2.6; 90% male) completed all study procedures. Relative to the no-medication condition, tics were reduced when children were given a single dose of dMPH. Behavioral reinforcement of tic suppression resulted in lower rates of tics compared to baseline, but dMPH did not enhance this suppression.Preliminary results indicate replication of prior studies of behavioral tic suppression in youths with TD and without ADHD. In addition, our findings indicate tic reduction (and not tic exacerbation) with acute dMPH challenge in children and adolescents with ADHD and TD.

Item Type: Paper
Uncontrolled Keywords: Adolescent Attention Deficit Disorder with Hyperactivity Central Nervous System Stimulants Child Combined Modality Therapy Cross-Over Studies Female Humans Male Methylphenidate Pilot Projects Reinforcement (Psychology) Tics Tourette Syndrome
Subjects: diseases & disorders > mental disorders
CSHL Authors:
Communities: CSHL labs > Lyon lab
Depositing User: Matt Covey
Date Deposited: 10 Dec 2012 20:14
Last Modified: 10 Dec 2012 21:11
PMCID: PMC2958463
URI: http://repository.cshl.edu/id/eprint/26294

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