Studies of RAS function in the yeast Saccharomyces cerevisiae

Wigler, M. H., Field, J., Powers, S., Broek, D., Toda, T., Cameron, S., Nikawa, J., Michaeli, T., Colicelli, J., Ferguson, K. (1988) Studies of RAS function in the yeast Saccharomyces cerevisiae. Cold Spring Harbor Symposia on Quantitative Biology, 53 (2). pp. 649-55. ISSN 00917451 (ISSN)

URL: https://www.ncbi.nlm.nih.gov/pubmed/3076094
DOI: 10.1101/SQB.1988.053.01.074

Abstract

The three mammalian RAS genes, Ha-ras, Ki-ras, and N-ras, are capable of the malignant transformation of cultured animal cells (Barbacid 1987). Mutations in these genes have been linked to a large number of human cancers (Barbacid 1987). These genes encode closely related proteins that bind guanine nucleotides (Scolnick et al. 1979; Shih et al. 1980; Ellis et al. 1981) and are localized to the inner surface of the plasma membrane (Willingham et al. 1980; Papageorge et al, 1982). Normal RAS proteins also slowly hydrolyze GTP (Gibbs et al. 1984; McGrath et al. 1984; Sweet et al. 1984). These properties are similar to those of the G proteins, which has led to the widespread expectation that RAS proteins, like G proteins, are involved in the transduction of membrane signals that are linked to cellular proliferation or differentiation.

Item Type: Paper
Additional Information: 0091-7451 Journal Article
Uncontrolled Keywords: Adenylate Cyclase metabolism Amino Acid Sequence Fungal Proteins genetics Genes Fungal Genes ras Genotype Molecular Sequence Data Mutation Saccharomyces cerevisiae enzymology genetics Signal Transduction ras Proteins
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > RAS
organism description > yeast > Saccharomyces
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > oncogene
CSHL Authors:
Communities: CSHL labs > Powers lab
CSHL labs > Wigler lab
Depositing User: CSHL Librarian
Date: 1988
Date Deposited: 11 Apr 2012 20:56
Last Modified: 08 Nov 2016 21:31
Related URLs:
URI: http://repository.cshl.edu/id/eprint/26242

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