Ras partners

Van Aelst, L., White, M., Wigler, M. H. (1994) Ras partners. Cold Spring Harbor Symposia on Quantitative Biology, 59. pp. 181-186. ISSN 00917451 (ISSN)

URL: https://www.ncbi.nlm.nih.gov/pubmed/7587068
DOI: 10.1101/SQB.1994.059.01.022

Abstract

The RAS oncogenes were first discovered as the transforming elements of acutely oncogenic retroviruses. Subsequently, cellular RAS genes were found to be frequently activated by mutation in a wide variety of human cancers, providing the first example of a common oncogenic mechanism. As a consequence, Ras proteins have been studied extensively (for review, see Barbacid 1987). RAS genes are found ubiquitously in eukaryotic organisms. They encode low-molecular-weight guanine nucleotide-binding proteins that hydrolyze GTP and localize to the inner surface of the plasma membrane after undergoing elaborate carboxy-terminal processing. Proteins that are involved in processing Ras, or in regulating its activity, e.g., by accelerating guanine nucleotide hydrolysis or exchange, have been largely conserved in evolution (for review, see Wigler 1993).

Item Type: Paper
Uncontrolled Keywords: Animals Binding Sites Genes ras Humans Mutation Protein Binding Protein Serine Threonine Kinases metabolism Proto-Oncogene Proteins metabolism proto oncogene Proto-Oncogene Proteins c-raf Saccharomyces cerevisiae genetics metabolism Schizosaccharomyces genetics metabolism Transfection ras Proteins genetics metabolism
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > RAS
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > oncogene
CSHL Authors:
Communities: CSHL labs > Van Aelst lab
CSHL labs > Wigler lab
Depositing User: CSHL Librarian
Date: 1994
Date Deposited: 11 Apr 2012 20:51
Last Modified: 22 Feb 2017 22:01
Related URLs:
URI: https://repository.cshl.edu/id/eprint/26240

Actions (login required)

Administrator's edit/view item Administrator's edit/view item
CSHL HomeAbout CSHLResearchEducationNews & FeaturesCampus & Public EventsCareersGiving