Genomic amplification and oncogenic properties of the KCNK9 potassium channel gene

Mu, D., Chen, L. Y., Zhang, X. P., See, L. H., Koch, C. M., Yen, C., Tong, J. J., Spiegel, L., Nguyen, K. C. Q., Servoss, A., Peng, Y., Pei, L., Marks, J. R., Lowe, S. W., Hoey, T., Jan, L. Y., McCombie, W. R., Wigler, M. H., Powers, S. (2003) Genomic amplification and oncogenic properties of the KCNK9 potassium channel gene. Cancer Cell, 3 (3). pp. 297-302. ISSN 1535-6108

URL: http://www.ncbi.nlm.nih.gov/pubmed/12676587
DOI: 10.1016/S1535-6108(03)00054-0

Abstract

Representational difference analysis (RDA) of human breast cancer was used to discover a novel amplicon located at chromosomal region 8q24.3. We examined a series of breast cancer samples harboring amplification of this region and determined that KCNK9 is the sole overexpressed gene within the amplification epicenter. KCNK9 encodes a potassium channel that is amplified from 3-fold to 10-fold in 10% of breast tumors and overexpressed from 5-fold to over 100-fold in 44% of breast tumors. Overexpression of KCNK9 in cell lines promotes tumor formation and confers resistance to both hypoxia and serum deprivation, suggesting that its amplification and overexpression plays a physiologically important role in human breast cancer.

Item Type: Paper
Uncontrolled Keywords: K+ CHANNEL channel TUMORS tumors HYBRIDIZATION hybridization PREDICTION prediction CLONING cloning TASK-3 Task-3 FAMILY family
Subjects: diseases & disorders > cancer > cancer types > breast cancer
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene amplification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene expression
CSHL Authors:
Communities: CSHL labs > Lowe lab
CSHL labs > McCombie lab
CSHL labs > Powers lab
CSHL labs > Wigler lab
Depositing User: CSHL Librarian
Date Deposited: 12 Apr 2012 13:54
Last Modified: 11 Apr 2013 20:09
Related URLs:
URI: http://repository.cshl.edu/id/eprint/26233

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