RAS function and protein kinase cascades

Marcus, S., Wigler, M. H., Xu, H. P., Ballester, R., Kawamukai, M., Polverino, A. (1993) RAS function and protein kinase cascades. Ciba Found Symp, 176. 53-61; discussion 61. ISSN 0300-5208 (Print)

URL: https://www.ncbi.nlm.nih.gov/pubmed/8299425
DOI: 10.1002/9780470514450.ch4

Abstract

This paper reviews recent progress in understanding the function of RAS in three systems: the budding yeast (Saccharomyces cerevisiae), the fission yeast (Schizosaccharomyces pombe) and Xenopus laevis oocytes. One of the functions of RAS in S. cerevisiae is the stimulation of adenylate cyclase. This leads to the activation of the cAMP-dependent protein kinases--a function that has probably not been conserved in evolution. The immediate function of RAS in S. pombe is not known, but it may lead to the activation of a protein kinase cascade. This cascade has likely been conserved in evolution and linkage between it and RAS can be demonstrated in cell-free extracts from Xenopus oocytes. The Xenopus cell-free system provides a means to test specific hypotheses about RAS function and to isolate targets of RAS.

Item Type: Paper
Uncontrolled Keywords: Adenylate Cyclase metabolism Animals Fungal Proteins physiology Oocytes cytology Protein Kinases metabolism Saccharomyces cerevisiae physiology Schizosaccharomyces physiology Xenopus laevis ras Proteins
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > RAS
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes > kinase
organism description > animal > Frog > xenopus
organism description > yeast
CSHL Authors:
Communities: CSHL labs > Wigler lab
Depositing User: CSHL Librarian
Date: 1993
Date Deposited: 11 Apr 2012 21:12
Last Modified: 24 Feb 2017 21:38
Related URLs:
URI: http://repository.cshl.edu/id/eprint/26226

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