Isolation and Preliminary Characterization of a Human Transforming Gene from T24 Bladder-Carcinoma Cells

Goldfarb, M., Shimizu, K., Perucho, M., Wigler, M. H. (1982) Isolation and Preliminary Characterization of a Human Transforming Gene from T24 Bladder-Carcinoma Cells. Nature, 296 (5856). pp. 404-409. ISSN 0028-0836

URL: https://www.ncbi.nlm.nih.gov/pubmed/7063039
DOI: 10.1038/296404a0

Abstract

DNA from T24, a cell line derived from a human bladder carcinoma, can induce the morphological transformation of NIH 3T3 cells. Using techniques of gene rescue to clone the gene responsible for this transformation, we have found that it is human in origin, less than 5 kilobase pairs in size and is homologous to a 1,100-base polyadenylated RNA species found in T24 and HeLa cells. Blot analysis indicates extensive restriction endonuclease polymorphism near this gene, in human DNAs.

Item Type: Paper
Subjects: diseases & disorders > cancer > cancer types > bladder cancer
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene expression
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > oncogene
CSHL Authors:
Communities: CSHL labs > Wigler lab
Depositing User: CSHL Librarian
Date: 1982
Date Deposited: 13 Apr 2012 20:34
Last Modified: 08 Nov 2016 16:02
Related URLs:
URI: http://repository.cshl.edu/id/eprint/26187

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