RAS proteins can induce meiosis in Xenopus oocytes

Birchmeier, C., Broek, D., Wigler, M. H. (December 1985) RAS proteins can induce meiosis in Xenopus oocytes. Cell, 43 (3 PART). pp. 615-622.

URL: https://www.ncbi.nlm.nih.gov/pubmed/2416466
DOI: 10.1016/0092-8674(85)90233-8

Abstract

Injection of human H-ras protein induces maturation of Xenopus oocytes; that is, progression from prophase to metaphase of meiosis. The oncogenic protein encoded by H-rasval12 is nearly a 100-fold more potent than the protein encoded by the wild-type gene. We do not observe any measurable increase or decrease in cyclic AMP concentration in injected oocytes, and the effects of H-ras protein are only partially blocked by cholera toxin. Our results suggest that not all, if any, of the effects of H-rasval12 protein in this system are mediated by adenylate cyclase.

Item Type: Paper
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > RAS
organism description > animal > developmental stage > embryo
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein characterization
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein expression
organism description > animal > Frog > xenopus
CSHL Authors:
Communities: CSHL labs > Wigler lab
Depositing User: CSHL Librarian
Date: December 1985
Date Deposited: 19 Apr 2012 14:55
Last Modified: 18 Nov 2016 16:46
Related URLs:
URI: http://repository.cshl.edu/id/eprint/26158

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