Conservation and divergence of RAS protein function during evolution

Birchmeier, C., Broek, D., Toda, T., Powers, S., Kataoka, T., Wigler, M. H. (1985) Conservation and divergence of RAS protein function during evolution. Cold Spring Harbor Symposia on Quantitative Biology, 50. pp. 721-725. ISSN 00917451 (ISSN)

URL: https://www.ncbi.nlm.nih.gov/pubmed/3007012
DOI: 10.1101/SQB.1985.050.01.089

Abstract

The ras genes were first isolated as the transforming genes of Harvey and Kirsten sarcoma virus (Ellis et al. 1981). At least three different ras genes, Ha-ras, Ki-ras, and N-ras, exist in mammals and code for three very similar 21-kD proteins (Shimizu et al. 1983b). The ras proteins are localized in the plasma membrane (Willingham et al. 1980), bind guanine nucleotides (Shih et al. 1980, 1982), and have weak GTPase activity (Gibbs et al. 1984; McGrath et al. 1984; Sweet et al. 1984). A large number of tumor cells contain structurally mutated ras genes that are capable of tumorigenic transformation of NIH-3T3 cells upon DNA-mediated gene transfer (Reddy et al. 1982; Tabin et al. 1982; Taparowsky et al. 1982; Capon et al. 1983; Shimizu et al. 1983a; Yuasa et al. 1983)

Item Type: Paper
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > RAS
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein characterization
CSHL Authors:
Communities: CSHL labs > Wigler lab
CSHL labs > Powers lab
Depositing User: CSHL Librarian
Date: 1985
Date Deposited: 19 Apr 2012 14:51
Last Modified: 24 Feb 2017 21:16
Related URLs:
URI: http://repository.cshl.edu/id/eprint/26157

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