Characterization of an activated human ros gene

Birchmeier, C., Birnbaum, D., Waitches, G., Fasano, O., Wigler, M. H. (1986) Characterization of an activated human ros gene. Molecular & Cellular Biology, 6 (9). pp. 3109-3116.

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URL: https://www.ncbi.nlm.nih.gov/pubmed/3785223
DOI: 10.1128/MCB.6.9.3109

Abstract

A human oncogene, mcf3, previously detected by a combination of DNA-mediated gene transfer and a tumorigenicity assay, derives from a human homolog of the avian v-ros oncogene. Both v-ros and mcf3 can encode a protein with homology to tyrosine-specific protein kinases, and both mcf3 and v-ros encode a potential transmembrane domain N terminal to the kinase domain. mcf3 probably arose during gene tranfer from a normal human ros gene by the loss of a putative extracellular domain. There do not appear to be any other gross rearrangements in the structure of mcf3.

Item Type: Paper
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene expression
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > oncogene
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein characterization
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes > kinase > tyrosine kinase
CSHL Authors:
Communities: CSHL labs > Wigler lab
Depositing User: CSHL Librarian
Date: 1986
Date Deposited: 19 Apr 2012 16:45
Last Modified: 04 Nov 2016 20:31
PMCID: PMC367045
Related URLs:
URI: http://repository.cshl.edu/id/eprint/26156

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