Transformation of Olfactory Representations in the Drosophila Antennal Lobe

Wilson, R. I., Turner, G. C., Laurent, G. (2004) Transformation of Olfactory Representations in the Drosophila Antennal Lobe. Science, 303 (5656). pp. 366-370. ISSN 00368075 (ISSN)

URL: http://www.ncbi.nlm.nih.gov/pubmed/14684826
DOI: 10.1126/science.1090782

Abstract

Molecular genetics has revealed a precise stereotypy in the projection of primary olfactory sensory neurons onto secondary neurons. A major challenge is to understand how this mapping translates into odor responses in these second-order neurons. We investigated this question in Drosophila using whole-cell recordings in vivo. We observe that monomolecular odors generally elicit responses in large ensembles of antennal lobe neurons. Comparison of odor-evoked activity from afferents and postsynaptic neurons in the same glomerulus revealed that second-order neurons display broader tuning and more complex responses than their primary afferents. This indicates a major transformation of odor representations, implicating lateral interactions within the antennal lobe.

Item Type: Paper
Uncontrolled Keywords: Cells Genes Neurology Odor responses Living systems studies genetics antenna article controlled study Drosophila glomerulus in vivo study molecular genetics nonhuman odor olfactory system postsynaptic membrane priority journal sensory nerve cell stereotypy synapse Action Potentials Animals Excitatory Postsynaptic Potentials GABA Antagonists Nervous System Physiology Neural Inhibition Neurons, Afferent Odors Olfactory Pathways Olfactory Receptor Neurons Patch-Clamp Techniques Picrotoxin Receptors, GABA-A Sense Organs Smell Synapses Arachnida Hexapoda Insecta
Subjects: organism description > animal > insect > Drosophila
organs, tissues, organelles, cell types and functions > tissues types and functions > neural networks
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons

organism description > animal behavior > olfactory
CSHL Authors:
Communities: CSHL labs > Turner lab
Depositing User: CSHL Librarian
Date Deposited: 11 Apr 2012 15:09
Last Modified: 14 Mar 2013 16:14
Related URLs:
URI: http://repository.cshl.edu/id/eprint/26146

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