Small RNAs as Guardians of the Genome

Malone, C. D., Hannon, G. J. (February 2009) Small RNAs as Guardians of the Genome. Cell, 136 (4). pp. 656-668. ISSN 0092-8674

URL: http://www.ncbi.nlm.nih.gov/pubmed/19239887
DOI: 10.1016/j.cell.2009.01.045

Abstract

Transposons populate the landscape of all eukaryotic genomes. Often considered purely genomic parasites, transposons can also benefit their hosts, playing roles in gene regulation and in genome organization and evolution. Peaceful coexistence with mobile elements depends upon adaptive control mechanisms, since unchecked transposon activity can impact long-term fitness and acutely reduce the fertility of progeny. Here, we review the conserved roles played by small RNAs in the adaptation of eukaryotes to coexist with their genomic colonists. An understanding of transposon-defense pathways has uncovered recurring themes in the mechanisms by which genomes distinguish "self" from "non-self" and selectively silence the latter.

Item Type: Paper
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > sRNA
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > transposons
CSHL Authors:
Communities: CSHL labs > Hannon lab
Watson School > Publications
Depositing User: Editor Margaret Fantz
Date: 20 February 2009
Date Deposited: 17 Apr 2012 17:18
Last Modified: 22 Sep 2014 18:32
PMCID: PMC2792755
Related URLs:
URI: http://repository.cshl.edu/id/eprint/26121

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