The Expanding Universe of Noncoding RNAs

Hannon, G. J., Rivas, F. V., Murchison, E. P., Steitz, J. A. (2006) The Expanding Universe of Noncoding RNAs. Cold Spring Harb Symp Quant Biol, 71. pp. 551-564. ISSN 1943-4456 (Electronic) 0091-7451 (Linking)

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URL: http://www.ncbi.nlm.nih.gov/pubmed/17381339
DOI: 10.1101/sqb.2006.71.064

Abstract

The 71st Cold Spring Harbor Symposium on Quantitative Biology celebrated the numerous and expanding roles of regulatory RNAs in systems ranging from bacteria to mammals. It was clearly evident that noncoding RNAs are undergoing a renaissance, with reports of their involvement in nearly every cellular process. Previously known classes of longer noncoding RNAs were shown to function by every possible means-acting catalytically, sensing physiological states through adoption of complex secondary and tertiary structures, or using their primary sequences for recognition of target sites. The many recently discovered classes of small noncoding RNAs, generally less than 35 nucleotides in length, most often exert their effects by guiding regulatory complexes to targets via base-pairing. With the ability to analyze the RNA products of the genome in ever greater depth, it has become clear that the universe of noncoding RNAs may extend far beyond the boundaries we had previously imagined. Thus, as much as the Symposium highlighted exciting progress in the field, it also revealed how much farther we must go to understand fully the biological impact of noncoding RNAs.

Item Type: Paper
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene expression
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > ncRNA
CSHL Authors:
Communities: CSHL labs > Hannon lab
Watson School > Publications
Depositing User: Editor Margaret Fantz
Date: 2006
Date Deposited: 17 Apr 2012 17:58
Last Modified: 19 Sep 2014 18:43
Related URLs:
URI: http://repository.cshl.edu/id/eprint/26102

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