Rigorous feedback control of cAMP levels in Saccharomyces cerevisiae

Nikawa, J., Cameron, S., Toda, T., Ferguson, K. M., Wigler, M. H. (November 1987) Rigorous feedback control of cAMP levels in Saccharomyces cerevisiae. Genes & Development, 1 (9). pp. 931-937.

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URL: https://www.ncbi.nlm.nih.gov/pubmed/2828175
DOI: 10.1101/gad.1.9.931

Abstract

We have isolated and characterized normal and mutant alleles of many of the genes of the RAS/adenylyl cyclase pathway of the yeast Saccharomyces cerevisiae. Manipulation of those genes has revealed a system for feedback control that can modulate cAMP levels over at least a 10,000-fold range. The feedback control depends upon the activity of the cAMP-dependent protein kinases and requires the presence of the CDC25 and RAS proteins. The capacity for such dramatic control of cAMP levels raises fundamental questions about the normal mechanism of action of the cAMP signaling system in yeast.

Item Type: Paper
Subjects: organism description > yeast > Saccharomyces
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein characterization
CSHL Authors:
Communities: CSHL labs > Wigler lab
Depositing User: CSHL Librarian
Date: 1 November 1987
Date Deposited: 05 Apr 2012 16:09
Last Modified: 07 Nov 2016 19:33
Related URLs:
URI: http://repository.cshl.edu/id/eprint/26032

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