sar1, a gene from Schizosaccharomyces pombe encoding a protein that regulates ras1

Wang, Y., Boguski, M., Riggs, M., Rodgers, L., Wigler, M. (1991) sar1, a gene from Schizosaccharomyces pombe encoding a protein that regulates ras1. Cell Regulation, 2 (6). pp. 453-465. ISSN 10442030 (ISSN)

URL: https://www.ncbi.nlm.nih.gov/pubmed/1883874

Abstract

Proper ras1 function is required for normal sexual function in the yeast Schizosaccharomyces pombe. We have found a gene in S. pombe, sar1, that encodes a product capable of regulating ras1 function. sar1 is a member of an expanding family of RAS GTPase-activating proteins (GAPs) that includes mammalian GAP, the yeast Saccharomyces cerevisiae IRA proteins, and the product of the human neurofibromatosis locus, NF1 sar1, like these other proteins, can complement the loss of IRA function in S. cerevisiae. Computer analysis shows that the highest degree of sequence conservation is restricted to a very small number of diagnostic residues represented by the motif Phe-Leu-Arg-X-X-X-Pro-Ala-X-X-X-Pro. We find no evidence that sar1 is required for the effector function of ras1.

Item Type: Paper
Additional Information: PubMed ID: 1883874
Uncontrolled Keywords: amino acid sequence article comparative study computer program gene expression regulation genetics molecular genetics nucleotide sequence oncogene ras phenotype plasmid Saccharomyces Saccharomyces cerevisiae sequence alignment Base Sequence Genes, ras Molecular Sequence Data Plasmids Software
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > RAS
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene expression
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > oncogene
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein expression
CSHL Authors:
Communities: CSHL labs > Wigler lab
Depositing User: CSHL Librarian
Date Deposited: 06 Apr 2012 14:24
Last Modified: 18 Nov 2016 17:32
PMCID: PMC361829
URI: http://repository.cshl.edu/id/eprint/25987

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