Wang, Y., Boguski, M., Riggs, M., Rodgers, L., Wigler, M.
(1991)
sar1, a gene from Schizosaccharomyces pombe encoding a protein that regulates ras1.
Cell Regulation, 2 (6).
pp. 453-465.
ISSN 10442030 (ISSN)
Abstract
Proper ras1 function is required for normal sexual function in the yeast Schizosaccharomyces pombe. We have found a gene in S. pombe, sar1, that encodes a product capable of regulating ras1 function. sar1 is a member of an expanding family of RAS GTPase-activating proteins (GAPs) that includes mammalian GAP, the yeast Saccharomyces cerevisiae IRA proteins, and the product of the human neurofibromatosis locus, NF1 sar1, like these other proteins, can complement the loss of IRA function in S. cerevisiae. Computer analysis shows that the highest degree of sequence conservation is restricted to a very small number of diagnostic residues represented by the motif Phe-Leu-Arg-X-X-X-Pro-Ala-X-X-X-Pro. We find no evidence that sar1 is required for the effector function of ras1.
| Item Type: |
Paper
|
| Additional Information: |
PubMed ID: 1883874 |
| Uncontrolled Keywords: |
amino acid sequence
article
comparative study
computer program
gene expression regulation
genetics
molecular genetics
nucleotide sequence
oncogene ras
phenotype
plasmid
Saccharomyces
Saccharomyces cerevisiae
sequence alignment
Base Sequence
Genes, ras
Molecular Sequence Data
Plasmids
Software
|
| Subjects: |
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > RAS
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene expression
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > oncogene
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein expression |
| CSHL Authors: |
|
| Communities: |
CSHL labs > Wigler lab |
| Depositing User: |
CSHL Librarian
|
| Date: |
1991 |
| Date Deposited: |
06 Apr 2012 14:24 |
| Last Modified: |
18 Nov 2016 17:32 |
| PMCID: |
PMC361829 |
| URI: |
https://repository.cshl.edu/id/eprint/25987 |
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