Thalamocortical dysrhythmia: A neurological and neuropsychiatric syndrome characterized by magnetoencephalography

Llinas, R. R., Ribary, U., Jeanmonod, D., Kronberg, E., Mitra, P. P. (December 1999) Thalamocortical dysrhythmia: A neurological and neuropsychiatric syndrome characterized by magnetoencephalography. Proceedings of the National Academy of Sciences, 96 (26). pp. 15222-15227.

URL: https://www.ncbi.nlm.nih.gov/pubmed/10611366
DOI: 10.1073/pnas.96.26.15222

Abstract

Spontaneous magnetoencephalographic activity was recorded in awake, healthy human controls and in patients suffering from neurogenic pain, tinnitus, Parkinson's disease, or depression. Compared with controls, patients showed increased low-frequency rhythmicity, in conjunction with a widespread and marked increase of coherence among high- and low-frequency oscillations. These data indicate the presence of a thalamocortical dysrhythmia, which we propose is responsible for all the above mentioned conditions. This coherent activity, the result of a resonant interaction between thalamus and cortex, is due to the generation of low-threshold calcium spike bursts by thalamic cells. The presence of these bursts is directly related to thalamic cell hyperpolarization, brought about by either excess inhibition or disfacilitation. The emergence of positive clinical symptoms is viewed as resulting from ectopic -band activation, which we refer to as the "edge effect." This effect is observable as increased coherence between low- and high-frequency oscillations, probably resulting from inhibitory asymmetry between high- and low-frequency thalamocortical modules at the cortical level.

Item Type: Paper
Subjects: diseases & disorders > nervous system diseases and disorders
Investigative techniques and equipment > electrophysiology
organism description > animal > mammal > primates > hominids > human
Investigative techniques and equipment > imaging
CSHL Authors:
Communities: CSHL labs > Mitra lab
Depositing User: CSHL Librarian
Date: 2 December 1999
Date Deposited: 04 Apr 2012 19:33
Last Modified: 06 Feb 2017 21:33
PMCID: PMC24801
Related URLs:
URI: http://repository.cshl.edu/id/eprint/25848

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