The strength and periodicity of D. melanogaster circadian rhythms are differentially affected by alterations in period gene expression

Liu, X., Yu, Q., Huang, Z., Zwiebel, L. J., Hall, J. C., Rosbash, M. (1991) The strength and periodicity of D. melanogaster circadian rhythms are differentially affected by alterations in period gene expression. Neuron, 6 (5). pp. 753-766. ISSN 08966273 (ISSN)

URL: http://www.ncbi.nlm.nih.gov/pubmed/1902699
DOI: 10.1016/0896-6273(91)90172-v

Abstract

The per gene of D. melanogaster influences or participates in the generation of biological rhythms. Previous experiments have identified the head as the location from which per exerts its effect on circadian rhythms. To localize further this region and to examine the effects of altered levels and altered spatial expression patterns of the per gene on circadian rhythms of locomotor activity, we have characterized transformed lines containing per gene constructs missing substantial cis-acting regulatory information. The data suggest that wild-type levels of per gene expression are necessary in only a small fraction of the nervous system for near wild-type periods, whereas a larger fraction of per-expressing cells in the brain contributes to the strength of the circadian rhythms.

Item Type: Paper
Uncontrolled Keywords: article brain circadian rhythm drosophila gene expression immunohistochemistry nonhuman northern blotting polymerase chain reaction priority journal Animal Base Sequence Blotting Northern Drosophila melanogaster Female Genotype Locomotion Male Molecular Sequence Data Nervous System Physiology Plasmids Proteins Transcription Genetic Transformation Genetic
Subjects: organism description > animal > insect > Drosophila
organs, tissues, organelles, cell types and functions > organs types and functions > brain
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene expression
CSHL Authors:
Communities: CSHL labs > Huang lab
Depositing User: CSHL Librarian
Date Deposited: 10 Apr 2012 16:10
Last Modified: 10 May 2013 19:19
Related URLs:
URI: http://repository.cshl.edu/id/eprint/25810

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