Transient neurites of retinal horizontal cells exhibit columnar tiling via homotypic interactions

Huckfeldt, R. M., Schubert, T., Morgan, J. L., Godinho, L., Di Cristo, G., Huang, Z. J., Wong, R. O. L. (2009) Transient neurites of retinal horizontal cells exhibit columnar tiling via homotypic interactions. Nat Neurosci, 12 (1). 35 - 43 .

URL: https://www.ncbi.nlm.nih.gov/pubmed/19060895
DOI: 10.1038/nn.2236

Abstract

Sensory neurons with common functions are often nonrandomly arranged and form dendritic territories that show little overlap, or tiling. Repulsive homotypic interactions underlie such patterns in cell organization in invertebrate neurons. It is unclear how dendro-dendritic repulsive interactions can produce a nonrandom distribution of cells and their spatial territories in mammalian retinal horizontal cells, as mature horizontal cell dendrites overlap substantially. By imaging developing mouse horizontal cells, we found that these cells transiently elaborate vertical neurites that form nonoverlapping columnar territories on reaching their final laminar positions. Targeted cell ablation revealed that the vertical neurites engage in homotypic interactions that result in tiling of neighboring cells before the establishment of their dendritic fields. This developmental tiling of transient neurites correlates with the emergence of a nonrandom distribution of the cells and could represent a mechanism that organizes neighbor relationships and territories of neurons before circuit assembly.

Item Type: Paper
Uncontrolled Keywords: DEVELOPING MOUSE RETINA developing mouse retina DROSOPHILA SENSORY NEURONS Drosophila sensory neurons PATTERN-FORMATION pattern formation GANGLION-CELLS ganglion cells DENDRITIC INTERACTIONS dendritic interactions MIGRATION migration MECHANISMS mechanisms MOSAICS mosaics CONE cone DIFFERENTIATION differentiation
Subjects: organs, tissues, organelles, cell types and functions > cell types and functions > cell types > dendritic cells
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > dendritic cells
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > dendritic cells

organism description > animal > mammal > rodent > mouse
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons

organs, tissues, organelles, cell types and functions > tissues types and functions > retina
CSHL Authors:
Communities: CSHL labs > Huang lab
Depositing User: CSHL Librarian
Date Deposited: 10 Apr 2012 15:29
Last Modified: 10 Jan 2017 15:28
PMCID: PMC2743396
Related URLs:
URI: http://repository.cshl.edu/id/eprint/25805

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