BDNF regulates the maturation of inhibition and the critical period of plasticity in mouse visual cortex

Huang, Z. J., Kirkwood, A., Pizzorusso, T., Porciatti, V., Morales, B., Bear, M. F., Maffei, L., Tonegawa, S. (1999) BDNF regulates the maturation of inhibition and the critical period of plasticity in mouse visual cortex. Cell, 98 (6). pp. 739-755. ISSN 00928674 (ISSN)

URL: http://www.ncbi.nlm.nih.gov/pubmed/10499792
DOI: 10.1016/s0092-8674(00)81509-3

Abstract

Maturation of the visual cortex is influenced by visual experience during an early postnatal period. The factors that regulate such a critical period remain unclear. We examined the maturation and plasticity of the visual cortex in transgenic mice in which the postnatal rise of brain-derived neurotrophic factor (BDNF) was accelerated. In these mice, the maturation of GABAergic innervation and inhibition was accelerated. Furthermore, the age- dependent decline of cortical long-term potentiation induced by white matter stimulation, a form of synaptic plasticity sensitive to cortical inhibition, occurred earlier. Finally, transgenic mice showed a precocious development of visual acuity and an earlier termination of the critical period for ocular dominance plasticity. We propose that BDNF promotes the maturation of cortical inhibition during early postnatal life, thereby regulating the critical period for visual cortical plasticity.

Item Type: Paper
Uncontrolled Keywords: brain derived neurotrophic factor animal experiment animal model animal tissue article brain depth stimulation controlled study eye dominance gabaergic transmission long term potentiation mouse nerve cell plasticity nonhuman postnatal development priority journal regulatory mechanism synaptic inhibition transgenic mouse visual acuity visual cortex white matter Age Factors Animals Animals, Newborn Base Sequence Brain-Derived Neurotrophic Factor Cerebral Cortex Evoked Potentials Interneurons Long Term Potentiation long-term Mice Mice, Transgenic Molecular Sequence Data Neural Inhibition Neuronal Plasticity Parvalbumins Perception Prosencephalon Pyramidal Cells Receptors GABA Recombinant Proteins Time Factors Tissue Distribution Transgenes Animalia Mus musculus
Subjects: organism description > animal > mammal > rodent > mouse
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > neural plasticity
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons

organs, tissues, organelles, cell types and functions > tissues types and functions > visual cortex
CSHL Authors:
Communities: CSHL labs > Huang lab
Depositing User: CSHL Librarian
Date Deposited: 10 Apr 2012 18:37
Last Modified: 10 May 2013 19:02
Related URLs:
URI: http://repository.cshl.edu/id/eprint/25803

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