Biophysical model of a Hebbian synapse

Zador, A. M., Koch, C., Brown, T. H. (1990) Biophysical model of a Hebbian synapse. Proceedings of the National Academy of Sciences of the United States of America, 87 (17). pp. 6718-6722. ISSN 00278424 (ISSN)

URL: https://www.ncbi.nlm.nih.gov/pubmed/2168555

Abstract

We present a biophysical model of electrical and Ca2+ dynamics following activation of N-methyl-D-aspartate (NMDA) receptors located on a dendritic spine. The model accounts for much of the phenomenology of the induction of long-term potentiation at a Hebbian synapse in hippocampal region CA1. Computer simulations suggested four important functions of spines in this Ca2+-dependent synaptic modification: (i) compartmentalizing transient changes in [Ca2+] to just those synapses that satisfy the conjunctive requirement for synaptic modification; (ii) isolating the spine head from changes in the [Ca2+] at the dendritic shaft; (iii) amplifying the concentration changes at those synapses; and (iv) increasing the voltage dependence of the processes underlying long-term potentiation induction. This proposed role of spines in the regulation of Ca2+ dynamics contrasts with traditional approaches to spine function that have stressed electrotonic properties. This model can be used to explore the computational implications of Hebbian synapses.

Item Type: Paper
Uncontrolled Keywords: Ca2+ dynamics Hebb's postulate long-term potentiation neuronal plasticity spines article long term potentiation nerve cell plasticity nonbiological model physical model priority journal synapse Animal Biophysics Calcium Models, Neurological Receptors, N-Methyl-D-Aspartate Receptors, Neurotransmitter Spine Synapses Synaptic Transmission
Subjects: bioinformatics > genomics and proteomics > small molecules > NMDA receptor
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > dendritic cells > dendritic spines
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > dendritic cells > dendritic spines
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > dendritic cells > dendritic spines

organs, tissues, organelles, cell types and functions > tissues types and functions > hippocampus
CSHL Authors:
Communities: CSHL labs > Zador lab
Depositing User: Leigh Johnson
Date Deposited: 27 Mar 2012 20:55
Last Modified: 23 Feb 2017 21:26
Related URLs:
URI: http://repository.cshl.edu/id/eprint/25641

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