Postsynaptic receptor trafficking underlying a form of associative learning

Rumpel, S., LeDoux, J., Zador, A. M., Malinow, R. (April 2005) Postsynaptic receptor trafficking underlying a form of associative learning. Science, 308 (5718). pp. 83-8. ISSN 1095-9203 (Electronic)

URL: http://www.ncbi.nlm.nih.gov/pubmed/15746389
DOI: 10.1126/science.1103944

Abstract

To elucidate molecular, cellular, and circuit changes that occur in the brain during learning, we investigated the role of a glutamate receptor subtype in fear conditioning. In this form of learning, animals associate two stimuli, such as a tone and a shock. Here we report that fear conditioning drives AMPA-type glutamate receptors into the synapse of a large fraction of postsynaptic neurons in the lateral amygdala, a brain structure essential for this learning process. Furthermore, memory was reduced if AMPA receptor synaptic incorporation was blocked in as few as 10 to 20% of lateral amygdala neurons. Thus, the encoding of memories in the lateral amygdala is mediated by AMPA receptor trafficking, is widely distributed, and displays little redundancy.

Item Type: Paper
Uncontrolled Keywords: Amygdala cytology metabolism physiology virology Animals Association Learning physiology Conditioning (Psychology) Electrophysiology Fear Female Genetic Vectors Green Fluorescent Proteins metabolism Long Term Potentiation Male Memory physiology Neural Pathways physiology Neuronal Plasticity Neurons metabolism physiology virology Patch Clamp Techniques Protein Transport Rats Rats, Sprague-Dawley Receptors AMPA metabolism Recombinant Fusion Proteins metabolism Simplexvirus genetics Synapses metabolism physiology Synaptic Transmission Thalamus physiology
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > AMPA receptor
organism description > animal behavior > fear
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > glutamate receptor
organism description > animal behavior > learning
CSHL Authors:
Communities: CSHL labs > Malinow lab
CSHL labs > Zador lab
Depositing User: Leigh Johnson
Date: 1 April 2005
Date Deposited: 28 Mar 2012 19:03
Last Modified: 01 Mar 2013 20:31
Related URLs:
URI: http://repository.cshl.edu/id/eprint/25611

Actions (login required)

Administrator's edit/view item Administrator's edit/view item
CSHL HomeAbout CSHLResearchEducationNews & FeaturesCampus & Public EventsCareersGiving