Long-Lasting Context Dependence Constrains Neural Encoding Models in Rodent Auditory Cortex

Asari, H., Zador, A. M. (2009) Long-Lasting Context Dependence Constrains Neural Encoding Models in Rodent Auditory Cortex. J Neurophysiol, 102 (5). pp. 2638-56.

URL: http://www.ncbi.nlm.nih.gov/pubmed/19675288
DOI: 10.1152/jn.00577.2009

Abstract

Acoustic processing requires integration over time. We have used in vivo intracellular recording to measure neuronal integration times in anesthetized rats. Using natural sounds and other stimuli, we found that synaptic inputs to auditory cortical neurons showed a rather long context-dependence, up to four seconds or longer ({tau}~1 s), even though sound-evoked excitatory and inhibitory conductances per se rarely lasted longer than ~100 ms. Thalamic neurons showed only a much faster form of adaptation with a decay constant {tau}<100 ms, indicating that the long-lasting form originated from presynaptic mechanisms in the cortex, such as synaptic depression. Restricting knowledge of the stimulus history to only a few hundred milliseconds reduced the predictable response component to about half of that of the optimal infinite-history model. Our results demonstrate the importance of longrange temporal effects in auditory cortex, and suggest a potential neural substrate for auditory processing that requires integration over time scales of seconds or longer, such as stream segregation.

Item Type: Paper
Subjects: organs, tissues, organelles, cell types and functions > tissues types and functions > auditory cortex
bioinformatics > computational biology
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons

organism description > animal > mammal > rodent > rat
organism description > animal > mammal > rodent > rat
CSHL Authors:
Communities: CSHL labs > Zador lab
Watson School > Publications
Depositing User: Leigh Johnson
Date Deposited: 28 Mar 2012 19:02
Last Modified: 22 Sep 2014 16:46
PMCID: PMC2777827
Related URLs:
URI: http://repository.cshl.edu/id/eprint/25605

Actions (login required)

Administrator's edit/view item Administrator's edit/view item
CSHL HomeAbout CSHLResearchEducationNews & FeaturesCampus & Public EventsCareersGiving