ben Functions with Scamp during Synaptic Transmission and Long-Term Memory Formation in Drosophila

Zhao, H., Zheng, X., Yuan, X., Wang, L., Wang, X., Zhong, Y., Xie, Z., Tully, T. (January 2009) ben Functions with Scamp during Synaptic Transmission and Long-Term Memory Formation in Drosophila. J Neurosci, 29 (2). pp. 414-424.

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URL: https://www.ncbi.nlm.nih.gov/pubmed/19144841
DOI: 10.1523/jneurosci.5036-07.2009

Abstract

Genetic screens for Drosophila mutants defective in pavlovian olfactory memory have provided unique insight into the molecular basis of memory storage. Occasionally, these singular genetic lesions have been assembled into meaningful molecular pathways and neural circuitries. For the most part, however, these genes and their expression patterns in the CNS remain fragmented, demanding new clues from continued mutant screens. From a behavioral screen for long-term memory (LTM) mutants, we have identified ben (CG32594), which encodes a novel protein. Mutations of ben specifically disrupt LTM, leaving earlier memory phases intact. The role of ben appears physiological rather than developmental, because acutely induced expression of a ben+ transgene in adults rescues the mutant's LTM defect. More interestingly, induced expression of ben+ specifically in mushroom bodies (MBs), but not in the ellipsoid body of the central complex, is sufficient to rescue the mutant LTM defect. This suggests a role for ben in the MB during olfactory memory formation. We also provide evidence that BEN interacts genetically in both synaptic transmission and LTM formation with SCAMP, a synaptic protein known to be involved in vesicle recycling.

Item Type: Paper
Uncontrolled Keywords: olfactory learning synaptic transmission mutants larval neuromuscular junction mutant learning and memory neurotransmission
Subjects: organism description > animal > insect > Drosophila
organism description > animal behavior > learning
organism description > animal behavior > olfactory
CSHL Authors:
Communities: CSHL labs > Zhong lab
Depositing User: CSHL Librarian
Date: 14 January 2009
Date Deposited: 29 Mar 2012 19:41
Last Modified: 06 Nov 2017 20:59
PMCID: PMC3045784
Related URLs:
URI: http://repository.cshl.edu/id/eprint/25597

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