Suppressor of hairless is required for long-term memory formation in drosophila

Song, Q., Sun, K., Shuai, Y. C., Lin, R., You, W., Wang, L., Zhong, Y. (July 2009) Suppressor of hairless is required for long-term memory formation in drosophila. Journal of Neurogenetics, 23 (4). pp. 405-411.

URL: https://www.ncbi.nlm.nih.gov/pubmed/19863271
DOI: 10.3109/01677060903096133

Abstract

Suppressor of Hairless [Su(H)] is a DNA-binding protein of the Notch-signaling pathway, which is important for developmental processes and has been implicated in behavior plasticity. It acts as a transcriptional activator in the Notch pathway, but also as a repressor in the absence of Notch signaling. Our previous work has shown that Notch signaling contributes to long-term memory formation in the Drosophila adult brain. In the present report, we show that Su(H) null heterozygous mutants perform normally for learning, early memory, and anesthesia-resistant memory, whereas long-term memory is impaired. Interestingly, we find overexpressing wild- type Su(H) also causes long-term memory defect in Drosophila. Significantly, induction of a heat-shock inducible Su(H)+ transgene before training can fully rescue the memory defect of Su(H) mutants, thereby demonstrating an acute role for Su(H) in behavioral plasticity. We show that Su(H) is widely expressed in the adult brain. Transgenic expression of wild-type Su(H) in the Mushroom Bodies is sufficient to rescue the memory defect of Su(H) mutants. Our data clearly demonstrate that transcriptional activity of Su(H) in Notch signaling in the mushroom bodies is critical for the formation of long-term memory. © 2009 Informa UK Ltd All rights reserved.

Item Type: Paper
Uncontrolled Keywords: Long term memory Mushroom bodies Notch signaling Suppressor of Hairless
Subjects: organism description > animal > insect > Drosophila
organism description > animal behavior > memory
organs, tissues, organelles, cell types and functions > tissues types and functions > mushroom body
CSHL Authors:
Communities: CSHL labs > Zhong lab
Depositing User: CSHL Librarian
Date: 13 July 2009
Date Deposited: 29 Mar 2012 19:36
Last Modified: 13 Mar 2018 19:13
Related URLs:
URI: http://repository.cshl.edu/id/eprint/25596

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