Receptor-like tyrosine phosphatase PTP10D is required for long-term memory in Drosophila

Qian, M., Pan, G., Sun, L., Feng, C., Xie, Z., Tully, T., Zhong, Y. (2007) Receptor-like tyrosine phosphatase PTP10D is required for long-term memory in Drosophila. Journal of Neuroscience, 27 (16). pp. 4396-4402. ISSN 02706474 (ISSN)

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URL: http://www.ncbi.nlm.nih.gov/pubmed/17442824
DOI: 10.1523/jneurosci.4054-06.2007

Abstract

Tyrosine phosphorylation mediates multiple signal transduction pathways that play key roles in developmental processes and behavioral plasticity. The level of tyrosine phosphorylation is regulated by protein tyrosine kinases and protein tyrosine phosphatases (PTPs). Extensive studies have investigated the roles of tyrosine kinases in memory formation. However, there were few studies on PTPs. To date, learning has been shown to be defective only for mouse knock-outs of PTPα, leukocyte common antigen-related, or PTPδ. A major limitation of these studies arises from their inability to distinguish an acute (biochemical) impairment ofmemoryformation from a more chronic abnormality in neurodevelopment. From a behavioral screen for defective long-term memory, we found chi mutants to disrupt expression of the PTP10D protein tyrosine phosphatase gene. We show that chi mutants are normal for learning, early memory, and anesthesia-resistant memory, whereas long-term memory specifically is abolished. Significantly, induction of a heat shock-PTP10D+ transgene before training fully rescues the memory defect of chi mutants, thereby demonstrating an acute role for PTP10D in behavioral plasticity. We show that PTP10D is widely expressed in the embryonic CNS and in the adult brain. Transgenic expression of upstream activating sequence-PTP10D+ in mushroom bodies is sufficient to rescue the memory defect of chi mutants. Our data clearly demonstrate that signaling through PTP10D in mushroom bodies is critical for the formation of long-term memory. Copyright © 2007 Society for Neuroscience.

Item Type: Paper
Uncontrolled Keywords: Behavior chi Long term memory Mushroom bodies PTP10D Screen CD45 antigen esterase protein tyrosine kinase tyrosine phosphatase unclassified drug anesthesia article central nervous system controlled study Drosophila gene mutation knockout mouse learning long term memory mouse mushroom body nerve cell differentiation nerve cell plasticity nonhuman priority journal protein expression protein phosphorylation signal transduction transgene Animals Animals Genetically Modified Brain Drosophila Proteins Memory Protein Tyrosine Phosphatase
Subjects: organism description > animal > insect > Drosophila
organism description > animal behavior > memory
organs, tissues, organelles, cell types and functions > tissues types and functions > mushroom body
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes > protein tyrosine phosphatase
CSHL Authors:
Communities: CSHL labs > Zhong lab
Depositing User: CSHL Librarian
Date: 2007
Date Deposited: 29 Mar 2012 15:48
Last Modified: 28 Feb 2013 17:48
PMCID: PMC3045567
Related URLs:
URI: http://repository.cshl.edu/id/eprint/25587

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