Precision and diversity in an odor map on the olfactory bulb

Soucy, E. R., Albeanu, D. F., Fantana, A. L., Murthy, V. N., Meister, M. (2009) Precision and diversity in an odor map on the olfactory bulb. Nature Neuroscience, 12 (2). pp. 210-220. ISSN 10976256 (ISSN)

URL: http://www.ncbi.nlm.nih.gov/pubmed/19151709
DOI: 10.1038/nn.2262

Abstract

We explored the map of odor space created by glomeruli on the olfactory bulb of both rat and mouse. Identified glomeruli could be matched across animals by their response profile to hundreds of odors. Their layout in different individuals varied by only ∼1 glomerular spacing, corresponding to a precision of 1 part in 1,000. Across species, mouse and rat share many glomeruli with apparently identical odor tuning, arranged in a similar layout. In mapping the position of a glomerulus to its odor tuning, we found only a coarse relationship with a precision of ∼5 spacings. No chemotopic order was apparent on a finer scale and nearby glomeruli were almost as diverse in their odor sensitivity as distant ones. This local diversity of sensory tuning stands in marked distinction from other brain maps. Given the reliable placement of the glomeruli, it represents a feature, not a flaw, of the olfactory bulb. © 2009 Nature America, Inc. All rights reserved.

Item Type: Paper
Uncontrolled Keywords: animal cell animal experiment article brain mapping brain region diagnostic imaging female hemisphere Long Evans rat male mouse nonhuman olfactory bulb olfactory discrimination olfactory epithelium priority journal rat Wistar rat Animals Green Fluorescent Proteins Mice Mice, Mutant Strains Models, Neurological Odors Olfactory Pathways Olfactory Receptor Neurons Rats Rats, Long-Evans Rats, Wistar Receptors, Odorant Smell
Subjects: organism description > animal behavior > odor recognition
organs, tissues, organelles, cell types and functions > tissues types and functions > olfactory bulb
organism description > animal > mammal > rodent
CSHL Authors:
Communities: CSHL labs > Albeanu lab
Depositing User: CSHL Librarian
Date Deposited: 19 Mar 2012 20:45
Last Modified: 03 Apr 2015 14:28
Related URLs:
URI: http://repository.cshl.edu/id/eprint/25441

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