Analysis of drug pharmacology towards predicting drug behavior by expression profiling using high-density oligonucleotide arrays

Hu, J. S., Durst, M., Kerb, R., Truong, V., Ma, J. T., Khurgin, E., Balaban, D., Gingeras, T. R., Hoffman, B. B. (2000) Analysis of drug pharmacology towards predicting drug behavior by expression profiling using high-density oligonucleotide arrays. Annals of the New York Academy of Sciences, 919. pp. 9-15. ISSN 00778923 (ISSN)

URL: http://www.ncbi.nlm.nih.gov/pubmed/11083092
DOI: 10.1111/j.1749-6632.2000.tb06862.x

Abstract

An important aspect of the drug development process is prediction of efficacious and toxic side effects. Profiling of mRNA expression is a powerful approach to analyze the molecular phenotype of cells under various conditions, for example, in response to stimulation by compounds. We attempt to explore the approach of using expression profiling to identify patterns or fingerprints that are correlated with specific drug properties or behaviors. Identification of such expression patterns may also lead to revelation of the potential action mechanism of drugs and fingerprints indicative of certain drug efficacy or side effects. We describe here a strategy that was used to identify a set of genes whose differential expression pattern correlates with activation mode and target specificity of a specific group of drug compounds.

Item Type: Paper
Additional Information:
Uncontrolled Keywords: adrenergic receptor blocking agent adrenergic receptor stimulating agent drug messenger RNA animal cell conference paper DNA fingerprinting DNA microarray drug classification drug effect drug specificity drug targeting gene activation gene expression human human cell methodology nonhuman principal component analysis statistical analysis Algorithms Cell Line Drug Toxicity Gene Expression Profiling Humans Muscle Smooth Vascular Oligonucleotide Array Sequence Analysis RNA, Messenger Signal Transduction Software Substrate Specificity Toxicity Tests Animalia
Subjects: diseases & disorders > cancer > drugs and therapies
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene expression
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > mRNA dynamics
CSHL Authors:
Communities: CSHL labs > Gingeras lab
Depositing User: CSHL Librarian
Date: 2000
Date Deposited: 14 Mar 2012 16:18
Last Modified: 27 Mar 2014 20:23
Related URLs:
URI: http://repository.cshl.edu/id/eprint/25357

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