Emergence of dual resistance to zidovudine and lamivudine in HIV-1- infected patients treated with zidovudine plus lamivudine as initial therapy

Kuritzkes, D. R., Shugarts, D., Bakhtiari, M., Poticha, D., Johnson, J., Rubin, M., Gingeras, T. R., Kennedy, M., Eron, J. J. (2000) Emergence of dual resistance to zidovudine and lamivudine in HIV-1- infected patients treated with zidovudine plus lamivudine as initial therapy. Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, 23 (1). pp. 26-34. ISSN 10779450 (ISSN)

URL: http://www.ncbi.nlm.nih.gov/pubmed/10708053

Abstract

Presence of mutations associated with resistance to zidovudine or lamivudine was determined in isolates of HIV-1 obtained after long-term follow-up of 64 infected individuals who received zidovudine, lamivudine, or both drugs as initial antiretroviral therapy. Zidovudine resistance mutations were less frequent in isolates from patients treated with combination lamivudine plus zidovudine compared with zidovudine alone, but these mutations accumulated over time. Phenotypic resistance to both drugs was found in isolates from 3 of 23 patients. In 3 other patients, lamivudine- resistant virus detected at week 12 was replaced by wild-type virus after longer follow-up, which correlated with a return to baseline levels of plasma HIV-1 RNA. These results show that dual resistance to zidovudine and lamivudine develops over time despite the delayed emergence of zidovudine- resistant mutations. These results also suggest a selective advantage in vivo for HIV-1 species that are wild-type at RT codon 184.

Item Type: Paper
Uncontrolled Keywords: Dual resistance Lamivudine Zidovudine virus RNA amino acid sequence article blood level clinical trial combination chemotherapy follow up gene mutation genotype human Human immunodeficiency virus 1 Human immunodeficiency virus infection major clinical study multidrug resistance mutation rate phenotype priority journal revertant Anti-HIV Agents Codon Drug Resistance Microbial Drug Therapy Combination HIV Infections HIV-1 HIV-1 Reverse Transcriptase Humans Molecular Sequence Data Mutation Randomized Controlled Trials Reverse Transcriptase Inhibitors Sequence Homology Amino Acid Human immunodeficiency virus
Subjects: diseases & disorders > viral diseases > HIV
diseases & disorders > cancer > drugs and therapies
CSHL Authors:
Communities: CSHL labs > Gingeras lab
Depositing User: CSHL Librarian
Date: 2000
Date Deposited: 13 Mar 2012 14:52
Last Modified: 27 Mar 2014 20:26
Related URLs:
URI: http://repository.cshl.edu/id/eprint/25276

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