Initiation of DNA replication: Lessons from viral initiator proteins

Stenlund, A. (October 2003) Initiation of DNA replication: Lessons from viral initiator proteins. Nature Reviews Molecular Cell Biology, 4 (10). pp. 777-785. ISSN 1471-0072

URL: https://www.ncbi.nlm.nih.gov/pubmed/14504622
DOI: 10.1038/nrm1226

Abstract

Initiator proteins are key components of the DNA replication machinery that determine where initiation will occur. in the past few years, due to a greatly improved understanding of what viral initiators look like and how they function, we can now identify the basic tasks that are required of initiators, as well as begin to comprehend what activities are required to perform these tasks. The unproved knowledge of the viral initiators also demonstrates an unexpected level of conservation between different viral initiators, which fright extend also to their cellular counterparts.

Item Type: Paper
Uncontrolled Keywords: LARGE T-ANTIGEN Large T-antigen LARGE TUMOR-ANTIGEN Large Tumor antigen MINICHROMOSOME MAINTENANCE minichromosome maintenance PROTEIN protein ORIGIN RECOGNITION COMPLEX origin recognition complex DOUBLE-STRANDED-DNA double stranded DNA BOVINE PAPILLOMAVIRUS bovine papillomavirus HELICASE ACTIVITY helicase activity BINDING DOMAIN binding domain SV40 ORIGIN origin STRUCTURAL-CHANGES structural changes
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > DNA replication
organism description > virus > papillomavirus
CSHL Authors:
Communities: CSHL labs > Stenlund lab
Depositing User: Brian Soldo
Date: October 2003
Date Deposited: 15 Mar 2012 14:00
Last Modified: 14 Feb 2017 20:04
Related URLs:
URI: http://repository.cshl.edu/id/eprint/25182

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