Origin recognition and the chromosome cycle

Stillman, B. (2005) Origin recognition and the chromosome cycle. FEBS Letters, 579 (4). pp. 877-84. ISSN 00145793 (ISSN)

URL: http://www.ncbi.nlm.nih.gov/pubmed/15680967
DOI: 10.1016/j.febslet.2004.12.011

Abstract

Prior to the initiation of DNA replication, chromosomes must establish a biochemical mark that permits the recruitment in S phase of the DNA replication machinery that copies DNA. The process of chromosome replication in eukaryotes also must be coordinated with segregation of the duplicated chromosomes to daughter cells during mitosis. Protein complexes that utilize ATP coordinate events at origins of DNA replication and later they participate in the initiation of DNA replication. In eukaryotes, some of these proteins also play a part in later processes that ensure accurate inheritance of chromosomes in mitosis, including spindle attachment of chromosomes, accurate duplication of centrosomes and cytokinesis. A perspective of how ATP-dependent proteins accomplish this task in eukaryotes is discussed.

Item Type: Paper
Uncontrolled Keywords: Archaea physiology Cell Cycle physiology Chromosome Segregation Chromosomes metabolism DNA Replication physiology Eukaryotic Cells physiology Replication Origin physiology Simian virus 40 physiology
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > DNA replication
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > chromosomes, structure and function
CSHL Authors:
Communities: CSHL labs > Stillman lab
Highlight: Stillman, Bruce W.
Depositing User: CSHL Librarian
Date Deposited: 29 Feb 2012 15:08
Last Modified: 20 Jun 2017 18:14
Related URLs:
URI: http://repository.cshl.edu/id/eprint/25085

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