p63: a new link between senescence and aging

Keyes, W. M., Mills, A. A. (February 2006) p63: a new link between senescence and aging. Cell Cycle, 5 (3). pp. 260-265. ISSN 15384101

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URL: http://www.ncbi.nlm.nih.gov/pubmed/16434880
DOI: 10.4161/cc.5.3.2415

Abstract

Cellular senescence is a distinctive form of cell cycle arrest that has been suggested to modulate the processes of tumor suppression and aging. Though a detailed understanding of the cellular machinery regulating this process is emerging, a more thorough understanding of the key players linking senescence to organismal aging is needed. The recent discovery that loss of the p53-related protein p63 induces cellular senescence and causes features of accelerated aging provides further evidence that cellular senescence is intimately linked with organismal aging, and identifies p63 as a key regulator of both of these processes. ©2006 Landes Bioscience.

Item Type: Paper
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing
bioinformatics > genomics and proteomics
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > p63
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > senescence
CSHL Authors:
Communities: CSHL labs > Mills lab
Depositing User: Editor Margaret Fantz
Date: 1 February 2006
Date Deposited: 24 Feb 2012 16:13
Last Modified: 01 Mar 2013 15:46
Related URLs:
URI: http://repository.cshl.edu/id/eprint/24892

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