Evaluation of Depth Filtration for the Clarification of Perfusion Mammalian Cell Culture Harvest

Menon, M., Schroeder, J. B., Riske, F. (August 2005) Evaluation of Depth Filtration for the Clarification of Perfusion Mammalian Cell Culture Harvest. In: ACS National Conference 229, San Diego, CA..

URL: http://oasys2.confex.com/acs/229nm/techprogram/S16...

Abstract

Depth filtration was found to be an effective option for the clarification of perfusion cell culture harvests containing a glycosylated recombinant protein. This presentation will focus on the effect of process variables and feedstream characteristics on depth filtration performance, recovery, and capacity. The applicability of mathematical models available in literature for process modeling and the operational advantages of depth filtration over tangential flow microfiltration for the clarification of perfusion harvest will also be analyzed.

Item Type: Conference or Workshop Item (Paper)
Uncontrolled Keywords: Biotechnology depth filtration cell culture clarification diatomaceous earth
Subjects: bioinformatics > quantitative biology
biotechnology
biotechnology > filtration > depth filtration
biotechnology > initial clarification
biotechnology > filtration > depth filtration > absolute filtration > tangential flow filtration
CSHL Authors:
Depositing User: CSHL Librarian
Date: 28 August 2005
Date Deposited: 06 Dec 2011 22:36
Last Modified: 06 Dec 2011 22:36
URI: http://repository.cshl.edu/id/eprint/23247

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