A Brake Becomes an Accelerator: PTP1B-A New Therapeutic Target for Breast Cancer

Tonks, N. K., Muthuswamy, S. K. (March 2007) A Brake Becomes an Accelerator: PTP1B-A New Therapeutic Target for Breast Cancer. Cancer Cell, 11 (3). pp. 214-6. ISSN 1535-6108 (Print)

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URL: https://www.ncbi.nlm.nih.gov/pubmed/17349579
DOI: 10.1016/j.ccr.2007.02.022

Abstract

The protein tyrosine phosphatase PTP1B, previously recognized for its role in downregulating insulin and leptin signaling, has now been shown to function as a positive regulator of signaling events associated with breast tumorigenesis. Inhibitors of PTP1B that have been developed as drug candidates for treatment of diabetes and obesity may offer new avenues for the treatment of breast cancer.

Item Type: Paper
Subjects: diseases & disorders > cancer > cancer types > breast cancer
diseases & disorders > nutritional and metabolic diseases > diabetes
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes > protein tyrosine phosphatase
CSHL Authors:
Communities: CSHL labs > Muthuswamy lab
CSHL labs > Tonks lab
Depositing User: CSHL Librarian
Date: March 2007
Date Deposited: 01 Nov 2011 18:54
Last Modified: 21 Feb 2017 20:28
Related URLs:
URI: http://repository.cshl.edu/id/eprint/23158

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