Rapidly inducible, genetically targeted inactivation of neural and synaptic activity in vivo

Tervo, D. G. R., Karpova, A. Y. (2007) Rapidly inducible, genetically targeted inactivation of neural and synaptic activity in vivo. Current Opinion in Neurobiology, 17 (5). 581-586 .

[img]
Preview
PDF (Paper)
Rapidly inducible, genetically targeted inactivation.pdf - Published Version

Download (300Kb) | Preview
URL: http://www.ncbi.nlm.nih.gov/pubmed/18054219
DOI: 10.1016/j.conb.2007.10.002

Abstract

Inducible and reversible perturbation of the activity of selected neurons in vivo is critical to understanding the dynamics of brain circuits. Several genetically encoded systems for rapid inducible neuronal silencing have been developed in the past few years offering an arsenal of tools for in vivo experiments. Some systems are based on ion-channels or pumps, others on G protein coupled receptors, and yet others on modified presynaptic proteins. Inducers range from light to small molecules to peptides. This diversity results in differences in the various parameters that may determine the applicability of each tool to a particular biological question. Although further development would be beneficial, the current silencing tool kit already provides the ability to make specific perturbations of circuit function in behaving animals.

Item Type: Paper
Additional Information: 0959-4388 (Print)
Subjects: Investigative techniques and equipment
organs, tissues, organelles, cell types and functions > organs types and functions > brain
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
CSHL Authors:
Communities: CSHL labs > Svoboda lab
Watson School > Publications
Depositing User: CSHL Librarian
Date Deposited: 03 Nov 2011 14:34
Last Modified: 22 Sep 2014 15:16
PMCID: PMC2699994
Related URLs:
URI: http://repository.cshl.edu/id/eprint/23155

Actions (login required)

Administrator's edit/view item Administrator's edit/view item
CSHL HomeAbout CSHLResearchEducationNews & FeaturesCampus & Public EventsCareersGiving