p53: At the crossroad between cancer and ageing

Papazoglu, C., Mills, A. A. (January 2007) p53: At the crossroad between cancer and ageing. Journal of Pathology, 211 (2). pp. 124-133. ISSN 0022-3417

URL: https://www.ncbi.nlm.nih.gov/pubmed/17200941
DOI: 10.1002/path.2086

Abstract

The p53 tumour suppressor plays an undisputed role in cancer. p53's tumour suppressive activity stems from its ability to respond to a variety of stresses to trigger cell cycle arrest, apoptosis or senescence, thereby protecting against malignant transformation. An increasing body of evidence suggests that p53 also drives organismal ageing. Although genetic models with altered p53 function display age-related phenotypes and thus provide in vivo evidence that p53 contributes to the ageing process, p53's role in organismal ageing remains controversial. Anti-cancer therapies that target p53 and reactivate or enhance its activity are considered good alternatives for treating various neoplasms. Therefore, it is important to determine whether these clinical approaches compromise tissue homeostasis and contribute to ageing. This review presents a number of models with altered p53 function and discusses how these models implicate p53 as part of a molecular network that integrates tumour suppression and ageing. Copyright (c) 2007 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

Item Type: Paper
Uncontrolled Keywords: p53 senescence ageing mouse models EXTENDS LIFE-SPAN CALORIC RESTRICTION TUMOR SUPPRESSION OXIDATIVE STRESS DNA-DAMAGE WILD-TYPE EMBRYONIC LETHALITY CELLULAR SENESCENCE MDM2-DEFICIENT MICE CHECKPOINT KINASE
Subjects: diseases & disorders > neoplasms
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > apoptosis
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > p53
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > senescence
CSHL Authors:
Communities: CSHL labs > Mills lab
Depositing User: CSHL Librarian
Date: January 2007
Date Deposited: 07 Nov 2011 20:45
Last Modified: 02 Feb 2017 17:08
Related URLs:
URI: http://repository.cshl.edu/id/eprint/23117

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