Magnetic resonance spectroscopy identifies neural progenitor cells in the live human brain

Manganas, L. N., Zhang, X. Y., Li, Y., Hazel, R. D., Smith, S. D., Wagshul, M. E., Henn, F. A., Benveniste, H., Djuric, P. M., Enikolopov, G. N., Maletic-Savatic, M. (November 2007) Magnetic resonance spectroscopy identifies neural progenitor cells in the live human brain. Science, 318 (5852). pp. 980-985. ISSN 0036-8075

URL: https://www.ncbi.nlm.nih.gov/pubmed/17991865
DOI: 10.1126/science.1147851

Abstract

The identification of neural stem and progenitor cells (NPCs) by in vivo brain imaging could have important implications for diagnostic, prognostic, and therapeutic purposes. We describe a metabolic biomarker for the detection and quantification of NPCs in the human brain in vivo. We used proton nuclear magnetic resonance spectroscopy to identify and characterize a biomarker in which NPCs are enriched and demonstrated its use as a reference for monitoring neurogenesis. To detect low concentrations of NPCs in vivo, we developed a signal processing method that enabled the use of magnetic resonance spectroscopy for the analysis of the NPC biomarker in both the rodent brain and the hippocampus of live humans. Our findings thus open the possibility of investigating the role of NPCs and neurogenesis in a wide variety of human brain disorders.

Item Type: Paper
Uncontrolled Keywords: CENTRAL-NERVOUS-SYSTEM N-ACETYLASPARTATE DENTATE GYRUS ADULT BRAIN NEUROGENESIS STEM PROLIFERATION HIPPOCAMPUS DECREASE THERAPY
Subjects: Investigative techniques and equipment > biomarker
organs, tissues, organelles, cell types and functions > organs types and functions > brain
organs, tissues, organelles, cell types and functions > tissues types and functions > hippocampus
therapies > stem cells
CSHL Authors:
Communities: CSHL labs > Enikopolov lab
CSHL labs > Henn lab
Depositing User: CSHL Librarian
Date: November 2007
Date Deposited: 09 Nov 2011 20:56
Last Modified: 28 Feb 2017 21:46
PMCID: PMC4039561
Related URLs:
URI: http://repository.cshl.edu/id/eprint/23092

Actions (login required)

Administrator's edit/view item Administrator's edit/view item
CSHL HomeAbout CSHLResearchEducationNews & FeaturesCampus & Public EventsCareersGiving