Stem cells therapy for type 1 diabetes

Lu, P., Liu, F., Yan, L., Peng, T., Liu, T., Yao, Z., Wang, C. Y. (October 2007) Stem cells therapy for type 1 diabetes. Diabetes Research and Clinical Practice, 78 (1). pp. 1-7. ISSN 0168-8227

URL: http://www.ncbi.nlm.nih.gov/pubmed/17349714
DOI: 10.1016/j.diabres.2007.02.003

Abstract

In this article, we have reviewed the developments of studies of stem cells therapy for type I diabetes since this century. Review of the literature was based on computer searches (PubMed) and our studies. Type I diabetes can now be ameliorated by islet transplantation, but this treatment is restricted by the scarcity of islet tissue. Hopes for a limitless supply of a substitute for primary islets of Langerhans and progress in stem cell biology have led to research into the feasibility of stem/progenitor cells to generate insulin-producing cells to use in replacement therapies for diabetes. An increasing body of evidence indicated that, in addition to embryonic stem cells, several potential adult stem/progenitor cells, derived from pancreas, liver, spleen, and bone marrow could differentiate into insulin-producing cells in vitro or in vivo. However, significant controversy currently exists in this field. Moreover, safe suppression of autoimmunity or specific tolerance to auto-antigens for patients with type I diabetes must be achieved before this promising new technology can lead to a great progress in clinical practice. To prevent type I diabetes through genetic engineering of hematopoietic stem cells represents another new strategy. Much basic research is still required. (C) 2007 Elsevier Ireland Ltd. All rights reserved.

Item Type: Paper
Uncontrolled Keywords: diabetes mellitus differentiation stem cell pancreatic beta cell INSULIN-PRODUCING CELLS ANTIGEN-PRESENTING CELLS PANCREATIC BETA-CELLS BONE-MARROW IN-VITRO ISLET TRANSPLANTATION MULTIPOTENTIAL NESTIN REPLACEMENT THERAPY PROGENITOR CELLS ENDOCRINE-CELLS
Subjects: therapies
diseases & disorders > nutritional and metabolic diseases > diabetes
therapies > stem cells
CSHL Authors:
Communities: CSHL Post Doctoral Fellows
CSHL labs > Tonks lab
Depositing User: CSHL Librarian
Date: October 2007
Date Deposited: 11 Nov 2011 15:23
Last Modified: 03 May 2013 15:23
Related URLs:
URI: http://repository.cshl.edu/id/eprint/23084

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