Lu, P., Liu, F., Yan, L., Peng, T., Liu, T., Yao, Z., Wang, C. Y. (October 2007) Stem cells therapy for type 1 diabetes. Diabetes Research and Clinical Practice, 78 (1). pp. 1-7. ISSN 0168-8227
Abstract
In this article, we have reviewed the developments of studies of stem cells therapy for type I diabetes since this century. Review of the literature was based on computer searches (PubMed) and our studies. Type I diabetes can now be ameliorated by islet transplantation, but this treatment is restricted by the scarcity of islet tissue. Hopes for a limitless supply of a substitute for primary islets of Langerhans and progress in stem cell biology have led to research into the feasibility of stem/progenitor cells to generate insulin-producing cells to use in replacement therapies for diabetes. An increasing body of evidence indicated that, in addition to embryonic stem cells, several potential adult stem/progenitor cells, derived from pancreas, liver, spleen, and bone marrow could differentiate into insulin-producing cells in vitro or in vivo. However, significant controversy currently exists in this field. Moreover, safe suppression of autoimmunity or specific tolerance to auto-antigens for patients with type I diabetes must be achieved before this promising new technology can lead to a great progress in clinical practice. To prevent type I diabetes through genetic engineering of hematopoietic stem cells represents another new strategy. Much basic research is still required. (C) 2007 Elsevier Ireland Ltd. All rights reserved.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | diabetes mellitus differentiation stem cell pancreatic beta cell INSULIN-PRODUCING CELLS ANTIGEN-PRESENTING CELLS PANCREATIC BETA-CELLS BONE-MARROW IN-VITRO ISLET TRANSPLANTATION MULTIPOTENTIAL NESTIN REPLACEMENT THERAPY PROGENITOR CELLS ENDOCRINE-CELLS |
| Subjects: | therapies diseases & disorders > nutritional and metabolic diseases > diabetes therapies > stem cells |
| CSHL Authors: | |
| Communities: | CSHL Post Doctoral Fellows CSHL labs > Tonks lab |
| Depositing User: | CSHL Librarian |
| Date: | October 2007 |
| Date Deposited: | 11 Nov 2011 15:23 |
| Last Modified: | 03 May 2013 15:23 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/23084 |
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