A map of olfactory representation in the Drosophila mushroom body

Lin, H. H., Lai, J. S. Y., Chin, A. L., Chen, Y. C., Chiang, A. S. (March 2007) A map of olfactory representation in the Drosophila mushroom body. Cell, 128 (6). pp. 1205-1217. ISSN 0092-8674

URL: https://www.ncbi.nlm.nih.gov/pubmed/17382887
DOI: 10.1016/j.cell.2007.03.006

Abstract

Neural coding for olfactory sensory stimuli has been mapped near completion in the Drosophila first-order center, but little is known in the higher brain centers. Here, we report that the antenna lobe (AL) spatial map is transformed further in the calyx of the mushroom body (MB), an essential olfactory associated learning center, by stereotypic connections with projection neurons (PNs). We found that Kenyon cell (KC) dendrites are segregated into 17 complementary domains according to their neuroblast clonal origins and birth orders. Aligning the PN axonal map with the KC dendritic map and ultrastructural observation suggest a positional ordering such that inputs from the different AL glomeruli have distinct representations in the MB calyx, and these representations might synapse on functionally distinct KCs. Our data suggest that olfactory coding at the AL is decoded in the MB and then transferred via distinct lobes to separate higher brain centers.

Item Type: Paper
Uncontrolled Keywords: SHORT-TERM-MEMORY ANTENNAL LOBE COURTSHIP BEHAVIOR NEURONS BODIES BRAIN MELANOGASTER ORGANIZATION RECEPTORS NEUROTRANSMISSION
Subjects: organs, tissues, organelles, cell types and functions > cell types and functions > cell types > Kenyon cell
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > Kenyon cell
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > Kenyon cell

organs, tissues, organelles, cell types and functions > tissues types and functions > mushroom body
organs, tissues, organelles, cell types and functions > tissues types and functions > olfactory bulb
CSHL Authors:
Communities: CSHL labs > Tully lab
Depositing User: CSHL Librarian
Date: March 2007
Date Deposited: 11 Nov 2011 14:54
Last Modified: 30 Mar 2018 18:55
Related URLs:
URI: http://repository.cshl.edu/id/eprint/23080

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