Biological Rhythms Workshop IB: Neurophysiology of SCN Pacemaker Function

Kuhlman, S. J. (2007) Biological Rhythms Workshop IB: Neurophysiology of SCN Pacemaker Function. Cold Spring Harbor Symposia on Quantitative Biology, 72. pp. 21-33. ISSN 00917451 (ISSN)

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URL: http://symposium.cshlp.org/content/72/21.abstract
DOI: 10.1101/sqb.2007.72.061

Abstract

Pacemakers are functional units capable of generating oscillations that synchronize downstream rhythms. In mammals, the suprachiasmatic nucleus (SCN) of the hypothalamus is a circadian pacemaker composed of individual neurons that intrinsically express a near 24-hour rhythm in gene expression. Rhythmic gene expression is tightly coupled to a rhythm in spontaneous firing rate via intrinsic daily regulation of potassium current. Recent progress in the field indicates that SCN pacemaking is a specialized property that emerges from intrinsic features of single cells, structural connectivity among cells, and activity dynamics within the SCN. The focus of this chapter is on how Nature built a functional pacemaker from many individual oscillators that is capable of coordinating the daily timing of essential brain and physiological processes.

Item Type: Paper
Subjects: organs, tissues, organelles, cell types and functions > organs types and functions > brain
organs, tissues, organelles, cell types and functions > tissues types and functions > suprachiasmatic nucleus > hypothalamus
organs, tissues, organelles, cell types and functions > tissues types and functions > hypothalamus

organs, tissues, organelles, cell types and functions > tissues types and functions > suprachiasmatic nucleus
CSHL Authors:
Communities: CSHL labs > Huang lab
Depositing User: CSHL Librarian
Date: 2007
Date Deposited: 14 Nov 2011 16:51
Last Modified: 30 Mar 2018 15:09
URI: http://repository.cshl.edu/id/eprint/23073

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