microRNAs join the p53 network - another piece in the tumour-suppression puzzle

He, L., He, X., Lowe, S. W., Hannon, G. J. (November 2007) microRNAs join the p53 network - another piece in the tumour-suppression puzzle. Nat Rev Cancer, 7 (11). pp. 819-822. ISSN 1474-1768 (Electronic)

URL: https://www.ncbi.nlm.nih.gov/pubmed/17914404
DOI: 10.1038/nrc2232

Abstract

Several recent studies have found a conserved microRNA (miRNA) family, the miR-34s, to be direct transcriptional targets of p53. miR-34 activation can recapitulate elements of p53 activity, including induction of cell-cycle arrest and promotion of apoptosis, and loss of miR-34 can impair p53-mediated cell death. These data reinforce the growing awareness that non-coding RNAs are key players in tumour development by placing miRNAs in a central role in a well-known tumour-suppressor network.

Item Type: Paper
Subjects: diseases & disorders > cancer
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > transcription
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > miRNA
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > miRNA

bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > miR-34
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > p53
CSHL Authors:
Communities: CSHL labs > Hannon lab
CSHL labs > Lowe lab
Depositing User: CSHL Librarian
Date: November 2007
Date Deposited: 15 Nov 2011 15:29
Last Modified: 02 Dec 2016 15:52
PMCID: PMC4053212
Related URLs:
URI: http://repository.cshl.edu/id/eprint/23031

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