Locally dynamic synaptic learning rules in pyramidal neuron dendrites

Harvey, C. D., Svoboda, K. (December 2007) Locally dynamic synaptic learning rules in pyramidal neuron dendrites. Nature, 450 (7173). pp. 1195-1200. ISSN 0028-0836

URL: http://www.ncbi.nlm.nih.gov/pubmed/18097401
DOI: 10.1038/nature06416

Abstract

Long-term potentiation (LTP) of synaptic transmission underlies aspects of learning and memory. LTP is input-specific at the level of individual synapses, but neural network models predict interactions between plasticity at nearby synapses. Here we show in mouse hippocampal pyramidal cells that LTP at individual synapses reduces the threshold for potentiation at neighbouring synapses. After input-specific LTP induction by two-photon glutamate uncaging or by synaptic stimulation, subthreshold stimuli, which by themselves were too weak to trigger LTP, caused robust LTP and spine enlargement at neighbouring spines. Furthermore, LTP induction broadened the presynaptic–postsynaptic spike interval for spike-timing-dependent LTP within a dendritic neighbourhood. The reduction in the threshold for LTP induction lasted 10 min and spread over 10 m of dendrite. These local interactions between neighbouring synapses support clustered plasticity models of memory storage and could allow for the binding of behaviourally linked information on the same dendritic branch.

Item Type: Paper
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > Long term potentiation
organs, tissues, organelles, cell types and functions > tissues types and functions > hippocampus
organism description > animal behavior > learning
organism description > animal behavior > memory
organism description > animal > mammal > rodent > mouse
organs, tissues, organelles, cell types and functions > sub-cellular tissues: types and functions > synapse
CSHL Authors:
Communities: CSHL labs > Svoboda lab
Watson School > Publications
Depositing User: CSHL Librarian
Date: 20 December 2007
Date Deposited: 15 Nov 2011 15:00
Last Modified: 22 Sep 2014 14:55
PMCID: PMC3425382
Related URLs:
URI: http://repository.cshl.edu/id/eprint/23027

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